套细胞淋巴瘤研究进展

陈艳

【期刊名称】《实用肿瘤学杂志》 【年(卷),期】2012(026)004

【摘 要】套细胞淋巴瘤是B细胞非霍奇金淋巴瘤的一种特殊类型,以t(11;14)染色体易位和细胞周期蛋白D1阳性(Cyclin D1)过度表达为特征.大多数病人发病时即处于疾病晚期,常伴有结外受侵的侵袭性临床过程.单克隆抗体联合高剂量化疗包括自体干细胞移植(ASCT)使治疗有效率较前提高,新的作用于细胞周期和凋亡通路的药物,如蛋白酶体抑制剂、免疫调节剂、mTOR抑制剂等,也取得了令人鼓舞的疗效.%Mantle cell lymphoma(MCL)is a unique subtype of B - ceil non - Hodgkin lymphomas char-aeterized by the chromosomal transloeation t(11 ; 14)and nuclear eyelin Dl overegression in the vast majority of eases. Most patients present with advanced stage disease as well as often with extranodal dissemination, and pursue an aggressive clinical course in the majority of cases. Recent improvement has been achieved by the successful introduction of monoclonal antibodies and dose - intensified approaches including antologons stem cell transplan-tation(ASCT) strategies. Emerging strategies such as proteasome inhibitors, mTOR inhibitors and others are based on the dysregulated control of cell cycle machinery and impaired apoptotic pathways. It achieves encouraging results.

【总页数】4页(P377-380)

【作 者】陈艳

【作者单位】哈尔滨医科大学附属三院血液淋巴内科,哈尔滨,150081 【正文语种】中 文 【中图分类】R733.4 【相关文献】

1.依鲁替尼治疗套细胞淋巴瘤的研究进展 [J], 何虹秀

2.SOX11在套细胞淋巴瘤中的研究进展 [J], 刘雪娜(综述);孙成铭(审校) 3.套细胞淋巴瘤药物治疗的研究进展 [J], 周美玉;许国发;刘如燕 4.套细胞淋巴瘤诊治及预后研究进展 [J], 彭太芳(综述);陈林(审校) 5.套细胞淋巴瘤分子遗传学研究进展 [J], 雷卓(综述); 李文生(审校)

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