Orteronel_566939-85-3_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Orteronel566939-85-3HY-10505307.35C18H17N3O2>98%Solubility:DMSO ≥60mg/mL Water<1.2mg/mL Ethanol ≥60mg/mLMechanisms: Pathways:Metabolism/Protease; Target:Cytochrome P450 gyBiological Activity:Orteronel(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) iscurrently in phase III clinical trials for the treatment of castration-resistant prostate cancer. IC50 value: Target:References:[1]. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective17,20-lyase inhibitor with potential utility in the treatment of prostate cancer By Kaku, Tomohiro;Hitaka, Takenori; Ojida, Akio; Matsunaga, Nobuyuki; Adachi, Mari; Tanaka, Toshimasa; Hara,Takahito; Yamaoka, Masuo; Kusaka, Masami; Okuda, Teruaki; et al From Bioorganic & MedicinalgChemistry (2011), 19(21), 6383-6399. [2]. Gurav S, Police A, Zainuddin M, Farooqui JH, Reddy G K, Kethiri RR, Rajagopal S, Mullangi R. Development and validation of a highly sensitive LC-ESI-MS/MS method for the determination ofOrteronel(?) (TAK-700) in rat plasma: application to a pharmacokinetic study. Bioanalysis. 2012 Jun;4(12):1471-80. [3]. Gurav S, Police A, Zainuddin M, Punde RR, Dewang P, V C, Kethiri RR, Rajagopal S, MullangiR. DltdlidtiftDevelopment and validation of an enant...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr