专利名称：Nanogel-Mediated Drug Delivery发明人：Vinod Labhasetwar,Sivakumar
Vijayaraghavalu
申请号：US14046343申请日：20131004
公开号：US20140100182A1公开日：20140410
摘要：Provided herein are methods of inhibiting proliferation of one or more tumorcells comprising contacting the one or more tumor cells with a composition comprisingone or more epigenetic drugs that inhibit one or more epigenetic mechanisms of thetumor cells, wherein the one or more epigenetic drugs are encapsulated in a nanogel.The invention is also directed to methods of treating a tumor, metastasis of a tumor or acombination thereof in an individual in need thereof. The invention is also directed to amethod of sequentially delivering one or more epigenetic drugs that alter one or moreepigenetic mechanisms of a tumor cell and one or more chemotherapeutic drugs to anindividual that has a tumor. Compositions which comprise one or more epigenetic drugsthat alter one or more epigenetic mechanisms of a tumor cell, wherein the one or moreepigenetic drugs are encapsulated in a nanogel.
申请人：The Cleveland Clinic Foundation
地址：Cleveland OH US
国籍：US
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