专利名称：REGULATORY T CELLS AND METHODS OF
MAKING AND USING SAME
发明人：CHEROUTRE, Hilde,PARK, Yunji,MUCIDA,
Daniel, De Sousa,VICENTE-SUAREZ,Idelfonso
申请号：EP08771067.9申请日：20080613公开号：EP2167647A2公开日：20100331
摘要：Methods of stimulating or increasing differentiation to regulatory T cells,cultures of regulatory T cells and methods of reducing or decreasing an immuneresponse, inflammation or an inflammatory response, among other things, are provided.Methods include, among other things, contacting blood cells or T cells with an amount ofTGF-beta or a TGF-beta analogue and a retinoic acid receptor agonist, or an amount of aretinoid X receptor (RXR) or peroxisome proliferator activated receptor-gamma(PPARgamma) agonist, sufficient to stimulate or increase differentiation to regulatory Tcells. Cultures of regulatory T cells include T cells that express a marker associated withregulatory T cells, such as cultures in which regulatory T cells represent, for example,30% or more of the total number of cells in the culture.
申请人：LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
地址：9420 Athena Circle La Jolla, CA 92037 US
国籍：US
代理机构：Vossius & Partner
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