7-oxabicycloheptanesubstituted oxa prostaglandin a

专利名称：7-oxabicycloheptanesubstituted oxa

prostaglandin analgos useful in thetreatment of thrombolytic disease

发明人：Steven E. Hall,Martin F. Haslanger申请号：US06/653276申请日：19840924公开号：US04582854A公开日：19860415

摘要：7-Oxabicycloheptane substituted oxo prostaglandin analogs are providedhaving the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metalor trihydroxymethylaminomethane, R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl orcycloalkylalkyl, R.sup.2 is hydrogen or lower alkyl, A is --CH═CH-- or --(CH.sub.2).sub.2 --,n is 1 to 4, and m is 1 to 8, and including all stereoisomers thereof.< P>< P>Thecompounds are cardiovascular agents useful, for example, in the treatment ofthrombolytic disease.

申请人：E. R. SQUIBB & SONS, INC.

代理人：Lawrence S. Levinson,Burton Rodney

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